Definition of derange in US English:



[with object]
  • 1Cause (someone) to become insane.

    ‘that business last month must have deranged him a bit’
    • ‘You know, this is really a deranged person that would be taking these shots and killing people or injuring people.’
    • ‘We are not dealing with some deranged serial killer here, who has no sense of reality.’
    • ‘You're right Karen, most of my work has involved dealing with bizarre conspiracy theories told by people who often appear completely deranged.’
    • ‘People think of me as some kind of deranged comedian.’
    • ‘He should not be held responsible for this deranged man's actions.’
    • ‘But John was blameless: a happy and healthy family man cut down by a deranged fan on the way home from work.’
    • ‘He was a deranged murderer, but he wanted to save us from a government run amok.’
    • ‘But have you seen anything to suggest that he was part of any organized conspiracy, or was he just an isolated, deranged individual?’
    insane, mad, of unsound mind, out of one's mind, not in one's right mind, disturbed, unbalanced, unhinged, unstable, crazed, demented, irrational, berserk, frenzied, maniac, lunatic, psychopathic, certifiable, raving, raving mad
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    1. 1.1 Throw (something) into confusion; cause to act irregularly.
      ‘stress deranges the immune system’
      • ‘In scoliosis, the anatomy is deranged not only at each vertebral level but also between the convex and concave sides of the curve in the spine.’
      • ‘The group kicked proceedings off, squeezing their way into hormonally deranged teen hearts, with a crisp and punchy pop-punk-pounce.’
      • ‘It is well known that stress deranges the immune systems of human beings and non-human primates alike.’
      • ‘As when an individual soldier lost his balance, many flailing and falling soldiers deranged the enemy formation causing a serious decrease in the enemy's own firepower.’
      • ‘Several drugs have been shown to derange macrophage functions, bactericidal efficacy and production and secretion of cytokines.’
      • ‘Unforeseen accidents may derange our most profound schemes of policy.’
      • ‘In other patients, the genes preparing neurofilament proteins that support the nerve fibers are deranged.’
      • ‘In addition, antibiotic treatment deranges protective flora and antibiotic resistant microbial strains emerge.’
      • ‘Autosomal genes often showed deranged regulatory levels, indicating they were in pathways perturbed by X chromosomal changes.’
      • ‘My memory was deranged because of the new program.’
      • ‘Sometimes the stress deranges the managers' senses.’
    2. 1.2archaic Intrude on; interrupt.
      ‘I am sorry to have deranged you for so small a matter’
      • ‘From her gauze veiling the young woman spoke:-- "We are sorry to derange you. The guard made a mistake. Pardon!"’
      throw into confusion, throw into disorder, throw into disarray, cause confusion in, cause turmoil in, play havoc with, turn upside-down, make a mess of
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Late 18th century: from French déranger, from Old French desrengier, literally ‘move from orderly rows’.