Definition of derange in US English:



[with object]
  • 1Cause (someone) to become insane.

    ‘that business last month must have deranged him a bit’
    • ‘He should not be held responsible for this deranged man's actions.’
    • ‘He was a deranged murderer, but he wanted to save us from a government run amok.’
    • ‘You know, this is really a deranged person that would be taking these shots and killing people or injuring people.’
    • ‘But have you seen anything to suggest that he was part of any organized conspiracy, or was he just an isolated, deranged individual?’
    • ‘People think of me as some kind of deranged comedian.’
    • ‘You're right Karen, most of my work has involved dealing with bizarre conspiracy theories told by people who often appear completely deranged.’
    • ‘But John was blameless: a happy and healthy family man cut down by a deranged fan on the way home from work.’
    • ‘We are not dealing with some deranged serial killer here, who has no sense of reality.’
    insane, mad, of unsound mind, out of one's mind, not in one's right mind, disturbed, unbalanced, unhinged, unstable, crazed, demented, irrational, berserk, frenzied, maniac, lunatic, psychopathic, certifiable, raving, raving mad
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    1. 1.1 Throw (something) into confusion; cause to act irregularly.
      ‘stress deranges the immune system’
      • ‘Several drugs have been shown to derange macrophage functions, bactericidal efficacy and production and secretion of cytokines.’
      • ‘Autosomal genes often showed deranged regulatory levels, indicating they were in pathways perturbed by X chromosomal changes.’
      • ‘My memory was deranged because of the new program.’
      • ‘In addition, antibiotic treatment deranges protective flora and antibiotic resistant microbial strains emerge.’
      • ‘Unforeseen accidents may derange our most profound schemes of policy.’
      • ‘As when an individual soldier lost his balance, many flailing and falling soldiers deranged the enemy formation causing a serious decrease in the enemy's own firepower.’
      • ‘It is well known that stress deranges the immune systems of human beings and non-human primates alike.’
      • ‘Sometimes the stress deranges the managers' senses.’
      • ‘In other patients, the genes preparing neurofilament proteins that support the nerve fibers are deranged.’
      • ‘In scoliosis, the anatomy is deranged not only at each vertebral level but also between the convex and concave sides of the curve in the spine.’
      • ‘The group kicked proceedings off, squeezing their way into hormonally deranged teen hearts, with a crisp and punchy pop-punk-pounce.’
    2. 1.2archaic Intrude on; interrupt.
      ‘I am sorry to have deranged you for so small a matter’
      • ‘From her gauze veiling the young woman spoke:-- "We are sorry to derange you. The guard made a mistake. Pardon!"’
      throw into confusion, throw into disorder, throw into disarray, cause confusion in, cause turmoil in, play havoc with, turn upside-down, make a mess of
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Late 18th century: from French déranger, from Old French desrengier, literally ‘move from orderly rows’.