One of the mysteries of the English language finally explained.
The fact or condition of being tired out or exhausted; fatigue, (in later use often) specifically mental fatigue.
Early 16th century; earliest use found in John Fisher (c1469–1535), bishop of Rochester, cardinal, and martyr. From classical Latin dēfatīgātiōn-, dēfatīgātiō physical or mental exhaustion, state of being worn out from dēfatīgāt-, past participial stem of dēfatīgāre + -iō.
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