Definition of decompensation in US English:

decompensation

noun

Medicine
  • 1The failure of an organ (especially the liver or heart) to compensate for the functional overload resulting from disease.

    • ‘When liver decompensation occurs and if the patient is a suitable candidate, liver transplantation is the only treatment that extends life.’
    • ‘The major contributing factor for heart failure decompensation was medication lapses.’
    • ‘It is hoped that this strategy will prevent the problems associated with long-term volume overload and cardiac decompensation.’
    • ‘We excluded patients with hepatitis B, HIV infection, or hepatic decompensation.’
    • ‘Patients with chronic liver disease and signs of decompensation should be assessed for transplantation before they become critically ill.’
    1. 1.1Psychiatry The failure to generate effective psychological coping mechanisms in response to stress, resulting in personality disturbance or disintegration, especially that which causes relapse in schizophrenia.

Pronunciation

decompensation

/dēˌkämpənˈsāSH(ə)n/