Definition of cholecalciferol in US English:



  • One of the D vitamins, a sterol that is formed by the action of sunlight on dehydrocholesterol in the skin. Deficiency of this vitamin affects calcium levels, causing rickets in children and osteomalacia in adults.

    Also called "vitamin D3" (see vitamin D)
    • ‘All patients received 800 IU of cholecalciferol and 1,000 mg of calcium carbonate.’
    • ‘The most important source of vitamin D for all individuals is the sunlight-driven conversion in skin of 7-dehydrocholesterol to cholecalciferol.’
    • ‘Both groups received cholecalciferol and calcium carbonate oral supplementation.’
    • ‘The kidney is involved in the first step in metabolism of cholecalciferol to calcidiol, the form in which it is stored, and the liver in the final conversion to the active hormone calcitriol.’
    • ‘Vitamin D in the form of cholecalciferol reduces the risk of a first osteoporotic fracture in older people by about a quarter, but only when prescribed at a relatively high dose, say researchers from the United States.’