One of the mysteries of the English language finally explained.
An individual lesion of the rash of the disease chickenpox, consisting of a superficial vesicle. Also (in plural and formerly also in singular): the disease itself (now rare).
Mid 18th century; earliest use found in Daniel Turner (1667–1741), surgeon and physician. From chicken + pock, after chickenpox.
chicken pock/ˈtʃɪk(ɪ)n ˌpɒk/
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