Definition of biomarker in US English:

biomarker

noun

  • A measurable substance in an organism whose presence is indicative of some phenomenon such as disease, infection, or environmental exposure.

    ‘a biomarker that may predict aggressive disease recurrence in liver transplant recipients’
    • ‘The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen.’
    • ‘The compounds identified include biomarkers: compounds that can be related to identifiable biological chemical ‘species’.’
    • ‘In addition, a better integration will facilitate the discovery of genes for novel biomarkers and targets for new therapeutic interventions.’
    • ‘In our laboratory we have adapted a similar strategy to that reported by Liu et al. to perform on-line sample dialysis and clean-up for several protein biomarkers.’
    • ‘Plasma concentration of homocysteine is a good biomarker for folate deficiency.’
    • ‘Proteins linked to cancer may then serve as biomarkers to detect early disease and predict responsiveness to therapy or the likelihood of recurrence.’
    • ‘The gene expression biomarkers of caloric restriction can also be used to develop pharmaceuticals targeted to its genomic effects.’
    • ‘Several biomarker studies have examined the impact of vitamin E supplementation on biomarkers of DNA damage.’
    • ‘Diet is an important variable in determining DNA damage biomarkers, specifically micronuclei.’
    • ‘Your lab is now searching for biomarkers, proteins in the blood that are linked to the presence of particular cancers.’
    • ‘If biomarkers for the disease are present in the patient's sample, the lab-on-a-chip analysis will separate fluorescent antibodies bound to the biomarker from unbound antibodies.’
    • ‘If this were the case, increased intake of beta-carotene would not be expected to protect against disease since it was a biomarker of some other process and not indicative of low dietary intake.’
    • ‘Protein biomarkers offer great potential to improve the predictivity of animal studies and, in particular, provide the bridge between effects in animals and in man.’
    • ‘Moreover, it has helped us identify species and biomarkers that may better contribute to establishing the quality and extent of the toxicological impact.’
    • ‘Cytogenetic damage, evaluated as chromosomal aberrations, has been successfully applied as a reliable biomarker for chronic health risk.’
    • ‘A variance decomposition analysis was performed to reveal the extent to which platform error influenced the ability to identify biomarkers.’
    • ‘It is important to examine other biomarkers, such as chromosome aberrations and micronuclei, that relate to the damage still present after cellular processing.’
    • ‘Molecular diagnostics is a branch of clinical diagnostics that uses primarily DNA or RNA as a biomarker for clinical testing.’
    • ‘Under such circumstances, the identification of noninvasive or minimally invasive biomarkers of disease activity is essential.’
    • ‘Several biomarkers for genetic susceptibility which are also associated with increased cancer risk have been identified.’

Pronunciation

biomarker

/ˈbīōˌmärkər//ˈbaɪoʊˌmɑrkər/