Definition of bioavailability in US English:



  • The proportion of a drug or other substance which enters the circulation when introduced into the body and so is able to have an active effect.

    • ‘Clinicians and patients should beware of possible reductions in systemic bioavailability of conventional drugs when taken concomitantly with St John's wort.’
    • ‘Systemic bioavailability secondary to lung bioavailability definitely occurs, but the contribution is insignificant.’
    • ‘These effects may profoundly affect the oral bioavailability of drugs.’
    • ‘These parameters are influenced by the plasma clearance, volume of distribution and bioavailability of the drug.’
    • ‘Chapter sixteen has been written from the viewpoint of establishing bioavailability and bioequivalence of drugs and formulations.’