Definition of aromatase in US English:



  • An adrenal enzyme that converts androstenedione and estrone to estrogen. Inhibiting its action is one approach to breast cancer prevention and treatment.

    • ‘It binds to aromatase (the enzyme that converts testosterone to estrogen), holding it until it is destroyed.’
    • ‘A group of estrogen-blocking drugs called aromatase inhibitors have proven effective in preventing breast cancer from recurring after surgery.’
    • ‘Based on work done in other laboratories, Hayes' team suspects that atrazine feminizes the frogs by increasing production of an enzyme called aromatase, which converts testosterone to estrogen.’
    • ‘Additionally, ovarian differentiation can be altered by embryonic exposure to a inhibitor of aromatase, the enzyme essential for estrogen synthesis.’
    • ‘Chrysin, derived from Passiflora caerulea plants, does appear to block aromatase enzymes from converting testosterone to estrogen.’
    • ‘The American Institute of Cancer Research has awarded a two-year, $200,000 grant to scientists at City of Hope to identify the specific substance in mushrooms that suppresses aromatase, an enzyme that controls estrogen production.’
    • ‘Unlike most animals, many fish produce two forms of a gene responsible for the enzyme aromatase, which in turn makes estrogen.’
    • ‘Letrozole disables an enzyme called aromatase, which the body needs to make estrogen.’
    • ‘Researchers are investigating whether aromatase inhibitors can prevent breast cancer.’
    • ‘These have shown that tamoxifen alone is inadequate treatment (and so, probably, is treatment with aromatase inhibitors alone) and should be given only to very frail women with a life expectancy of less than a year.’
    • ‘Testosterone is converted to estrogen by aromatase enzymes that are present throughout the body, but the relationship between serum testosterone concentration levels and cognitive function in elderly women has not been studied.’
    • ‘Fat cells are a rich source of the aromatase enzyme that converts testosterone to estrogen.’
    • ‘Can you use tamoxifen or an aromatase inhibitor to prevent breast cancer in the first place?’
    • ‘Unlike other aromatase inhibitors, exemestane is a steroidal aromatase inactivator, which means it selectively targets and irreversibly binds to the aromatase enzyme, which is required to produce estrogen.’
    • ‘The brain cells in this area manufacture an enzyme called aromatase, which is involved in the action of testosterone.’
    • ‘Aromatase inhibitors reduce estrogen levels in a woman's body by preventing an enzyme called aromatase from converting other hormones to estrogen.’
    • ‘Excess fat contains an enzyme called aromatase, which converts some of your body's testosterone into estrogen and may lead to assorted abnormalities, such as gynecomastia (unsightly man-boobs).’
    • ‘Testosterone is actually converted to oestrogen as it enters the brain by an enzyme we call aromatase Not all of it, and we don't know how much of it's converted to oestrogen.’
    • ‘Goss and colleagues present data on the use of an aromatase inhibitor, letrozole, for prevention of breast cancer recurrence in women who have completed five years of tamoxifen therapy.’
    • ‘At low doses, atrazine induces aromatase and estrogen expression.’