Definition of amyotrophic lateral sclerosis in English:

amyotrophic lateral sclerosis

noun

  • A progressive degeneration of the motor neurons of the central nervous system, leading to wasting of the muscles and paralysis.

    • ‘Three main clinical variants are usually identified: progressive muscular atrophy, progressive bulbar palsy and amyotrophic lateral sclerosis.’
    • ‘Patients with alcoholism, drug abuse, cancer, multiple sclerosis, psychosis, amyotrophic lateral sclerosis, parkinsonism, Down syndrome, liver or kidney disease, epilepsy and stroke were excluded from the study.’
    • ‘The new development could one day help victims of spinal-cord injuries, or pave the way for novel treatments of degenerative diseases such as amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.’
    • ‘What I feared was wrong with her was amyotrophic lateral sclerosis, but I hemmed and hawed and told her that we needed to run some tests.’
    • ‘It is probably also beneficial in more rapidly progressive diseases, such as amyotrophic lateral sclerosis.’
    • ‘A selective defect in somatic muscle function producing oropharyngeal dysphagia can also occur in myasthenia gravis and in amyotrophic lateral sclerosis.’
    • ‘Respiratory muscle weakness is the usual cause of death in amyotrophic lateral sclerosis.’
    • ‘The year is 2003, and she has suffered with Lou Gehrig's disease, amyotrophic lateral sclerosis, for six years, which is longer than most patients with ALS last.’
    • ‘Most patients with advanced amyotrophic lateral sclerosis live in a functional locked-in state.’
    • ‘Other conditions, such as multiple sclerosis, amyotrophic lateral sclerosis and tumors on the spinal cord, can cause similar symptoms.’
    • ‘A new study reveals for the first time how gene mutations lead to the inherited form of amyotrophic lateral sclerosis, or Lou Gehrig's disease.’
    • ‘Two years later he died from a rare disease known as amyotrophic lateral sclerosis (a form of infantile paralysis).’
    • ‘Johns Hopkins researchers have found that transplants of mouse stem cells taken from the adult brain's olfactory bulb can delay symptoms and death in a mouse model of amyotrophic lateral sclerosis, or Lou Gehrig's disease.’
    • ‘A short time later he was diagnosed as having a rare and incurable disease called amyotrophic lateral sclerosis, or ALS, known in the United States as Lou Gehrig's disease after the Yankee baseball player who died from the illness.’
    • ‘Electromyography is indicated in patients with motor unit disorders, such as polymyositis, myasthenia gravis or amyotrophic lateral sclerosis.’
    • ‘The symptom is also sometimes seen in lobotomy patients and other sufferers of frontal lobe damage and in victims of amyotrophic lateral sclerosis (Lou Gehrig's disease) and multiple sclerosis.’
    • ‘Historically, up to one third of persons in every village developed a complex neurologic syndrome with clinical features of amyotrophic lateral sclerosis, parkinsonism, and dementia.’
    • ‘The differential diagnosis includes any condition that can result in myelopathy, such as multiple sclerosis, amyotrophic lateral sclerosis and masses (such as metastatic tumors) that press on the spinal cord.’
    • ‘Then, in January of 2003, he was diagnosed with Lou Gehrig's disease, amyotrophic lateral sclerosis.’
    • ‘These brain cell losses are similar to those found in patients with brain diseases like amyotrophic lateral sclerosis and multiple sclerosis, as well as dementia and other degenerative neurological disorders.’

Origin

Late 19th century: amyotrophic from amyotrophy.

Pronunciation

amyotrophic lateral sclerosis

/ˌāˌmīəˌträfik ˌladərəl skləˈrōsəs/