Definition of agranulocytosis in US English:



  • A deficiency of granulocytes in the blood, causing increased vulnerability to infection.

    • ‘Routine monitoring of white cell counts remains controversial, but results of one study showed that close monitoring of white cell counts allowed for earlier detection of agranulocytosis.’
    • ‘The latter one leads to agranulocytosis; hence monitoring blood investigations is necessary.’
    • ‘None of the patients on the drug developed agranulocytosis.’
    • ‘In the United Kingdom the drug may only be prescribed by registered consultant psychiatrists; this reflects the serious adverse effect profile of the drug, which includes agranulocytosis.’
    • ‘When reviewers repeated the trial years later, in a larger population, they found the incidence of this agranulocytosis was much lower than previously thought.’


Early 20th century: from a- + granulocyte + -osis.