One of the mysteries of the English language finally explained.
A synthetic compound used to lower blood sugar levels in the treatment of diabetes.
Alternative name: 1-butyl-3-tosylurea; chemical formula: C₁₂H₁₈N₂O₃S
- ‘Alcohol-extracted charantin from Momordica charantia consists of mixed steroids and was found to be more potent than the oral hypoglycemic agent tolbutamide in an animal study.’
- ‘Examples of sulfonylureas include tolbutamide, chlorpropamide, glyburide and glipizide.’
- ‘In some studies, karela extract has shown more hypoglycemic effects than the drug tolbutamide.’
- ‘Based on studies of the distribution of first-generation sulfonylureas into breast milk, the AAP considers tolbutamide to be compatible with breast-feeding.’
- ‘For example, sulfonamides used for infection were noted to lower blood sugar and led to drugs such as tolbutamide for diabetes.’
1950s: from tol(uene) + but(yl) + amide.
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