Definition of thrombin in English:



mass nounBiochemistry
  • An enzyme in blood plasma which causes the clotting of blood by converting fibrinogen to fibrin.

    • ‘Big, long, expensive programs against enzymes like elastase and thrombin went on year after year, but no one could get the things to quite work well enough.’
    • ‘The thrombin cleaves fibrinogen to an active monomer that polymerizes to form a fibrin meshwork.’
    • ‘In addition to its role in activation of fibrin clot formation, thrombin plays an important regulatory role in coagulation.’
    • ‘Fibrinogen is modified by thrombin to produce fibrin monomers that are the primary constituent of the fibrin clot.’
    • ‘The blood-clotting cascade ends in the formation of a substance that converts a blood protein called prothrombin into the protein thrombin, which actually forms the substance of the blood clot.’
    • ‘Protective mechanisms prevent thrombin and other procoagulant enzymes from forming in healthy intact blood vessels.’


Late 19th century: from Greek thrombos ‘blood clot’ + -in.