One of the mysteries of the English language finally explained.
A synthetic drug used in Alzheimer's disease to inhibit the breakdown of acetylcholine by cholinesterase and thereby enhance neurological function.
An acridine derivative; chemical formula: C₁₃H₁₅N₂Cl
- ‘The cholinesterase inhibitor tacrine is used rarely because of potential liver toxicity and the need for frequent laboratory monitoring.’
- ‘These effects are comparable to those of the drug tacrine, which is prescribed for Alzheimer's disease.’
- ‘There have been no direct comparison studies to tacrine or donepezil.’
- ‘Monitoring of serum transaminase levels is recommended with use of tacrine because of potential hepatotoxicity.’
- ‘The pharmacologic characteristics and side effects of tacrine make it a second-line agent.’
1960s: from t(etra-) + acr(id)ine.
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