Definition of tachyphylaxis in English:



mass nounMedicine
  • Rapidly diminishing response to successive doses of a drug, rendering it less effective. The effect is common with drugs acting on the nervous system.

    • ‘Trebling doses of histamine diphosphate were chosen instead of the usual doubling dose because of the half-life of lidocaine, the number of challenges, and the need to minimize possible tachyphylaxis of the histamine effect.’
    • ‘The efficacy of calcipotriene is comparable to mid-potency topical corticosteroids; however, it does not cause skin atrophy or tachyphylaxis.’
    • ‘Topical steroids should be applied no more than twice a day; more frequent use provides no advantage and may induce tachyphylaxis.’
    • ‘This spirometric improvement was maintained throughout the 13-week period without any evidence of tachyphylaxis.’
    • ‘Giving methotrexate concurrently, however, suppressed tachyphylaxis, probably by preventing the production of human antichimeric antibodies.’