One of the mysteries of the English language finally explained.
Originally: inoculation with material from a syphilitic lesion, as a (supposed) method of prevention or treatment for syphilis (now historical). In later use also: infection with syphilis.
Mid 19th century; earliest use found in The Lancet. From syphilize + -ation, after French syphilisation.
In this article we explore how to impress employers with a spot-on CV.