Definition of sticky end in English:

sticky end


  • An end of a DNA double helix at which a few unpaired nucleotides of one strand extend beyond the other.

    • ‘Such linkers could be joined by DNA ligase onto the DNA to be inserted and the resulting molecule cut with a restriction enzyme to generate sticky ends.’
    • ‘This created sticky ends on the dsRNA molecules which permitted efficient ligation.’
    • ‘This works because the enzyme will seek out the corresponding sticky ends on the target DNA, in essence cleaving or cutting out a certain section of the DNA.’
    • ‘Here, we have adapted a method we developed previously for the ligation of DNA triangles; we solve the phosphorylation requirement problem by restricting to create phosphorylated sticky ends.’
    • ‘DNA cyclization is achieved when the sticky ends come close enough together to form a duplex.’