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A severe hereditary form of anaemia in which a mutated form of haemoglobin distorts the red blood cells into a crescent shape at low oxygen levels. It is commonest among those of African descent.
- ‘In sickle-cell disease, the haemoglobin is abnormal and this causes a change in the shape of the red blood cells.’
- ‘An important breakthrough was the concept of molecular disease, introduced in the late 1940s with Linus Pauling's elucidation of the underlying basis of sickle-cell anemia.’
- ‘People with two copies of a form of a particular gene develop sickle-cell anemia, but people with one copy of that form show high resistance to malaria.’
- ‘His work focused on the antigen-antibody reaction and the structure of proteins and, in 1949, Pauling's team discovered the molecular basis of sickle-cell anemia.’
- ‘Thousands of children with thalassemia, sickle-cell anemia, Fanconi anemia, various leukemias, and certain other circulatory conditions could benefit from the same innovative battery of procedures.’
- ‘One out of four African Americans is born with alpha-thalassemia; therefore, at birth, one-fourth of African Americans with sickle-cell disease have this ameliorating condition.’
- ‘Humans are polymorphic for skin colour, body stature, sickle-cell anaemia, blood groups and the epicanthic eye-fold.’
- ‘One of the best-documented cases of pleiotropy is the gene associated with sickle-cell disease.’
- ‘In the study's earlier years, the first 12 children with sickle-cell disease received a bone marrow transplant plus busulfan and cyclophosphamide, two drugs known to facilitate transplants.’
- ‘A Blackpool group has organised an Afro-Caribbean night in the town to raise awareness of the hereditary blood disorder, sickle-cell anaemia.’
- ‘She talks about beauty basics, as well as major concerns affecting darker skins, such as the effects of sickle-cell disease, scars and keloids.’
- ‘Already the genes for many diseases, from sickle-cell anemia to heart disease, have been pinpointed, though genetic means of treating them are still in their infancy.’
- ‘The homozygous sickle-cell condition is responsible for the deadly effects of sickle-cell anemia, whereas the heterozygous condition is usually asymptomatic.’
- ‘In the simplest cases, such as sickle-cell anemia, diseases can be linked to a single gene.’
- ‘It says the school's use of race and ethnicity for research was similar to a medical school's use of Jewish patients to study Tay-Sachs disease, or Blacks to study sickle-cell anemia.’
- ‘Genetic changes in the hemoglobin molecule that affect the shape of the red blood cell and the oxygen carrying capacity of the cell result in the inheritable diseases of sickle-cell anemia and beta-thalassemia.’
- ‘My dad won the monthly National Science Prize when he designed a better cure for sickle-cell anemia.’
- ‘The blood condition sickle-cell anaemia is most common in people from Africa, the Caribbean, the eastern Mediterranean, the Middle East and Asia.’
- ‘Infection can produce severe anaemia and an aplastic crisis in people with sickle-cell anaemia or other abnormalities of haemoglobin.’
- ‘If an individual inherits the mutation in both genes they will have sickle-cell disease.’
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