Definition of sclerosis in English:



  • 1Medicine
    Abnormal hardening of body tissue.

    • ‘The lymph node biopsy showed sclerosis surrounding cellular nodules that contained clusters of large atypical cells admixed with small lymphocytes and numerous eosinophils.’
    • ‘In MS, myelin is lost in multiple areas, leaving scar tissue called sclerosis.’
    • ‘A close-up reveals the alternating areas of sclerosis and retained hepatic parenchyma in this nutmeg liver.’
    • ‘A doctor may suspect aortic valve sclerosis on hearing a heart murmur with a stethoscope.’
    • ‘It exhibited squamous differentiation, sclerosis, and eosinophilia.’
    1. 1.1A chronic, typically progressive disease involving damage to the sheaths of nerve cells in the brain and spinal cord, whose symptoms may include numbness, impairment of speech and of muscular coordination, blurred vision, and severe fatigue.
      • ‘The goal of treatment in patients with secondary progressive multiple sclerosis is to prevent progressive worsening of the disease.’
      • ‘Its expression in lung tissue has been widely described in systemic sclerosis, idiopathic pulmonary fibrosis and pulmonary sarcoidosis, and bleomycin-induced lung fibrosis.’
      • ‘Amyotrophic lateral sclerosis is a common neurologic disease associated with an inexorable decline in muscle strength.’
      • ‘A 67 year old woman with secondary progressive multiple sclerosis had a recurrence of right sided trigeminal neuralgia.’
      • ‘Among this latter group, there were four patients with rheumatoid arthritis, five with systemic sclerosis, three with systemic lupus erythematosus, five with dermatomyositis, and four with mixed connective tissue disease.’
      • ‘Other collagen diseases, such as progressive systemic sclerosis and systemic lupus erythematosus, are associated with increased incidence of pneumothorax.’
      • ‘The authors conclude that idiopathic pulmonary fibrosis associated with systemic sclerosis has the histopathologic pattern of nonspecific interstitial pneumonia, but that the histopathologic pattern does not predict prognosis.’
      • ‘In other pathologic states, such as systemic sclerosis or diabetes, the tissue elastic properties may prove more relevant.’
      • ‘An association between connective tissue diseases, particularly systemic sclerosis, and gastric antral vascular ectasia has been noted.’
      • ‘The purpose of this study was to evaluate the efficacy, safety, and effect on quality of life of outpatient sclerosis using small-bore pigtail catheters.’
      • ‘Glomerular sclerosis, manifested by proteinuria, progresses as patients age.’
      • ‘The obstructions are due in part to shortening of the mesentery from sclerosis and impairment of the enteric blood supply, which may result in further cicatrization, kinking and narrowing.’
      • ‘Around 16% of patients with sclerosis progress to stenosis in seven years.’
      • ‘Amyotrophic lateral sclerosis is a progressive disease affecting both upper and lower motor neurons.’
  • 2Excessive resistance to change.

    ‘the challenge was to avoid institutional sclerosis’
    • ‘In other words, this is a story not about institutional sclerosis, but about the necessarily contingent process of institutional change.’


Late Middle English (originally denoting a hard external tumour): via medieval Latin from Greek sklērōsis, from sklēroun harden.