One of the mysteries of the English language finally explained.
1A challenge made in return; a second or repeated challenge.
2Immunology and Medicine. The action of rechallenge; an instance of this.
1with object To challenge again.
2with object Immunology and Medicine. To treat (a patient or animal) again with a particular infectious agent, antigen, or drug, in order to test for immunity, hypersensitivity, or other type of (often adverse) reaction.
Early 18th century; earliest use found in Francis Bugg (1640–1727), Quaker apostate. From re- + challenge<br>early 18th century. From re- + challenge. Compare rechallenge.
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