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[mass noun] (in testing for antigens) the range of relative quantities of precipitin (or agglutinin) and antigen within which any precipitation (or agglutination) is inhibited by the predominance of one component.
- ‘In addition, these tests may show a ‘prozone’ phenomenon in which large amounts of antibody block the antibody-antigen reaction, causing a false-negative test in the undiluted sample.’
- ‘However, highly concentrated antibodies may result in a prozone effect, leading to decreased intensity of staining.’
Early 20th century: from pro- before + (agglutination) zone.
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