Definition of proguanil in English:



mass nounMedicine
  • A bitter-tasting synthetic compound derived from biguanide, used in the prevention and treatment of malaria.

    • ‘They had taken chloroquine weekly and proguanil daily for chemoprophylaxis against malaria.’
    • ‘Another study comparing four prophylactic regimens in civilian travelers found that overall tolerability was the same among mefloquine, doxycycline, chloroquine plus proguanil, and atovaquone plus proguanil.’
    • ‘Mefloquine is not standard treatment internationally, although alternative drugs such as atovaquone with proguanil or artemether with lumefantrine may help to manage uncomplicated malaria in an ambulatory setting.’
    • ‘Chloroquine with or without proguanil is used in some areas and Fansidar in others.’
    • ‘A separate combination, atovaquone plus proguanil, is active against malaria around the world.’


1940s: from pro(pyl) + (bi)guan(ide) (a crystalline base) + -il.