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A bitter-tasting synthetic compound derived from biguanide, used in the prevention and treatment of malaria.
- ‘Mefloquine is not standard treatment internationally, although alternative drugs such as atovaquone with proguanil or artemether with lumefantrine may help to manage uncomplicated malaria in an ambulatory setting.’
- ‘They had taken chloroquine weekly and proguanil daily for chemoprophylaxis against malaria.’
- ‘Chloroquine with or without proguanil is used in some areas and Fansidar in others.’
- ‘Another study comparing four prophylactic regimens in civilian travelers found that overall tolerability was the same among mefloquine, doxycycline, chloroquine plus proguanil, and atovaquone plus proguanil.’
- ‘A separate combination, atovaquone plus proguanil, is active against malaria around the world.’
1940s: from pro(pyl) + (bi)guan(ide) (a crystalline base) + -il.
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The definitions of ‘buddy’ and ‘bro’ in the OED have recently been revised. We explore their history and increase in popularity.