Definition of proenzyme in English:



  • A biologically inactive substance which is metabolized into an enzyme.

    • ‘Protein digestion begins in the stomach, where a proenzyme called pepsinogen is secreted, autocatalytically converted to Pepsin A, and used for the first step of proteolysis.’
    • ‘In the case of the serine proteases, they are synthesized as proenzymes, larger molecules that require modification before they become active.’
    • ‘All caspases, which are initially inactive proenzymes, share the same processing scheme to achieve mature forms after cleavage at specific Asp sites.’
    • ‘Covalent modification of pre-existing pools of inactive proenzymes produces active enzymes.’
    • ‘These death proteases are part of a proteolytic cascade activating proenzymes into active proteases.’