Definition of procoagulant in English:



  • Relating to or denoting substances that promote the conversion in the blood of the inactive protein prothrombin to the clotting enzyme thrombin.

    • ‘Thrombomodulin is an integral membrane glycoprotein that binds thrombin changing it from a procoagulant protein to an anticoagulant.’
    • ‘The cap acts as a protective barrier between circulating blood and the thrombogenic, procoagulant contents of the lesion.’
    • ‘Hemostasis involves the integration of many procoagulant proteins, natural anticoagulants, fibrinolytic proteins, and platelet surface glycoproteins.’
    • ‘Protective mechanisms prevent thrombin and other procoagulant enzymes from forming in healthy intact blood vessels.’
    • ‘In hemostasis, there is a balance between procoagulant factors and natural anticoagulant proteins.’


  • A procoagulant substance.

    • ‘Chemotherapy acts by killing leukemic cells, which release procoagulants that can produce disseminated intravascular coagulation.’
    • ‘When nitric oxide is deficient or used inadequately, endothelium becomes a procoagulant instead of an anticoagulant, and vasoactive molecules, cytokines, and growth factors are formed.’
    • ‘The exudate, procoagulants, and leukocytes form casts in the airways, resulting in poor gas exchange.’
    • ‘Taipan venom is overwhelmingly neurotoxic, including pre and post-synaptic neurotoxins, as well as powerful procoagulants and myolysins.’
    • ‘This phenomenon is attributed to platelet-aggregating factors and procoagulants from the tumor or its necrotic products.’