Definition of porcupine disease in English:

porcupine disease

noun

  • Ichthyosis hystrix gravior, an inherited (probably autosomal dominant) disorder of the skin characterized by the presence of patches of horny wart- or spine-like hyperkeratotic excrescences.

Origin

Mid 19th century; earliest use found in Robley Dunglison (1798–1869), physician and medical writer.