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A mutation affecting only one or very few nucleotides in a gene sequence.
- ‘So tell me how a simple point mutation changes the information content of the gene.’
- ‘If one of the alleles carries a recessive mutation, such as a point mutation, a second event that creates LOH could be any genetic alteration that inactivates the remaining allele.’
- ‘Each mutant allele contains a point mutation, and the positions of the Kitl sequences affected in each are shown in Table 1.’
- ‘To introduce a point mutation the gene must be cloned, the desired point mutation must be generated within that clone, and an I-SceI site must be inserted.’
- ‘Arrows indicate the position of the point mutation and the corresponding nucleotide on the wild-type sequence (right).’
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The definitions of ‘buddy’ and ‘bro’ in the OED have recently been revised. We explore their history and increase in popularity.