Definition of phentolamine in English:



mass nounMedicine
  • A synthetic compound used as a vasodilator, especially in certain cases of hypertension.

    • ‘The effectiveness of phentolamine can be seen immediately with a dramatic change in local skin color and temperature.’
    • ‘Severe hypertension can be treated with labetalol, phentolamine, nitroprusside, or similar agents.’
    • ‘Agitation and anxiety can be controlled with benzodiazepines, and hypertension with labetalol, phentolamine, or nitroprusside.’
    • ‘Epinephrine may interact with alpha- and beta-adrenergic blocking agents such as propranolol and phentolamine.’
    • ‘Tachycardia, prolonged hypotension, cardiac arrhythmias, weakness, dizziness, flushing, orthostatic hypotension, nausea, vomiting, and diarrhea are potential side effects of IV phentolamine.’


1950s: from phen- + tol(yl) (an isomeric cyclic radical derived from toluene) + amine.