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(of a molecule or group) having a tendency to donate electrons or react at electron-poor sites such as protons.Often contrasted with electrophilic
- ‘Methyl lithium is very reactive and acts as a nucleophilic methylating reagent to electrophilic functional groups, such as ketones.’
- ‘In the case of aldehydes and ketones containing carbonyl groups, the highly nucleophilic Grignard reagent contributes its electron pair to form a bond with the carbon atom.’
- ‘One highly characteristic reaction of aldehydes and ketones is nucleophilic addition to the carbon-oxygen double bond.’
- ‘The most common substitution reactions of compounds of non-metallic elements are nucleophilic and electrophilic substitution.’
- ‘EO is a direct-acting mutagen that reacts with nucleophilic molecules, including DNA, causing gene mutation and chromosome deletions in somatic cells.’
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