Definition of mithridatize in English:

mithridatize

(British mithridatise)

verb

[with object]rare
  • Make (someone) immune to a poison by administering gradually increasing doses of the poison.

    • ‘Few possibilities to stay awake at 4am, since I am completely mithridatized with caffeine since my student years: An espresso at 2am is 100% helpless, no effect at all.’
    • ‘The film is really very lovely, and I am NOT saying that because I am by now sufficiently mithridatized to no longer cringe when I see myself on a screen.’
    • ‘And to crown it all, it mithridatized the Ethiopian people to the future secession of Eritrea by incorporating the right of unconditional secession in the Transition Charter.’

Origin

Mid 19th century: from the name of Mithridates (see Mithridates VI), who reputedly made himself immune to poisons by constantly taking antidotes, + -ize.

Pronunciation

mithridatize

/mɪˈθrɪdətʌɪz/