Definition of mithridatize in English:

mithridatize

(also mithridatise)

verb

[WITH OBJECT]rare
  • Make (someone) immune to a poison by administering gradually increasing doses of the poison.

    • ‘And to crown it all, it mithridatized the Ethiopian people to the future secession of Eritrea by incorporating the right of unconditional secession in the Transition Charter.’
    • ‘Few possibilities to stay awake at 4am, since I am completely mithridatized with caffeine since my student years: An espresso at 2am is 100% helpless, no effect at all.’
    • ‘The film is really very lovely, and I am NOT saying that because I am by now sufficiently mithridatized to no longer cringe when I see myself on a screen.’

Origin

Mid 19th century: from the name of Mithridates (see Mithridates VI), who reputedly made himself immune to poisons by constantly taking antidotes, + -ize.

Pronunciation:

mithridatize

/mɪˈθrɪdətʌɪz/