Definition of macromutation in English:

macromutation

noun

Biology
  • A major genetic mutation, especially as a postulated cause or significant contributory factor in the evolution of new taxa; a mutation which causes a large shift in phenotype.

Origin

1940s. From macro- + mutation. Compare micromutation.

Pronunciation

macromutation

/ˌmakrəʊmjuːˈteɪʃn/