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1A complex of proteins associated with the centromere of a chromosome during cell division, to which the microtubules of the spindle attach.
- ‘In metaphase, sister kinetochores attach to microtubules emanating from opposite spindle pole bodies during alignment of the chromosomes.’
- ‘Chromosome loss may be the result of either non-attachment of the chromosome kinetochore to the spindle microtubules or chromosome lagging at anaphase and gives rise to a micronucleus.’
- ‘A second checkpoint pathway, the spindle checkpoint, operates at a similar point in meiosis, preventing progression into anaphase if the spindle apparatus fails to connect appropriately with kinetochores.’
- ‘This cohesion or ‘chiasma binder’ function ensures the generation of a bipolar spindle in which tension is generated at the kinetochores.’
- ‘The DNA is asymmetrically distributed to the daughter cells when the kinetochores do not attach and the spindle checkpoint does not restrain mitosis.’
- 1.1historical another term for centromere
1930s: from kineto- ‘of movement’ + Greek khōros ‘place’.
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