Definition of kinetochore in English:

kinetochore

noun

Biology
  • 1A complex of proteins associated with the centromere of a chromosome during cell division, to which the microtubules of the spindle attach.

    • ‘In metaphase, sister kinetochores attach to microtubules emanating from opposite spindle pole bodies during alignment of the chromosomes.’
    • ‘Chromosome loss may be the result of either non-attachment of the chromosome kinetochore to the spindle microtubules or chromosome lagging at anaphase and gives rise to a micronucleus.’
    • ‘A second checkpoint pathway, the spindle checkpoint, operates at a similar point in meiosis, preventing progression into anaphase if the spindle apparatus fails to connect appropriately with kinetochores.’
    • ‘This cohesion or ‘chiasma binder’ function ensures the generation of a bipolar spindle in which tension is generated at the kinetochores.’
    • ‘The DNA is asymmetrically distributed to the daughter cells when the kinetochores do not attach and the spindle checkpoint does not restrain mitosis.’
    1. 1.1historical
      another term for centromere

Origin

1930s: from kineto- ‘of movement’ + Greek khōros ‘place’.

Pronunciation

kinetochore

/kʌɪˈniːtəʊkɔː//kɪˈniːtəʊkɔː/