Definition of in silico in English:

in silico

adjective & adverb

  • (of scientific experiments or research) conducted or produced by means of computer modelling or computer simulation:

    [as adjective] ‘in silico analysis of the human genome’
    [adverb] ‘students who are too squeamish to dissect a frog can perform the procedure in silico’
    • ‘This in silico approach would be helpful in ranking textile dyes of the different classes based on their binding affinities.’
    • ‘In silico screening of the available genome sequences corroborated results.’
    • ‘We examine the essence by reconstituting it in silico.’
    • ‘This enables us to replicate cells in silico: we can simulate an increasing population of cells.’
    • ‘In silico analyses were completed to provide information about the possible cellular location of the protein.’
    • ‘In silico propagation of the charged particles yielded passage time values that are compatible with the measured average passage time of ions.’
    • ‘In silico results corroborated published laboratory findings.’
    • ‘In silico experiments can now be done on a wide variety of systems without the practical limitations that one may face in experimental approaches.’
    • ‘In silico analysis is not straight-forward either, but presents a necessary extension to current in vitro methods.’
    • ‘In silico strategies can be used to investigate the potential roles of a mutation on, for instance, protein stability.’


1980s: Latin, literally in silicon (with reference to the use of silicon chips in computer systems), on the pattern of in vitro and in vivo.


in silico

/ɪn ˈsɪlɪkəʊ/