Definition of imipramine in English:



mass nounMedicine
  • A synthetic compound used to treat depression.

    A tricyclic amine; chemical formula: C₁₉H₂₄N₂

    Also called Tofranil (a trademark)
    • ‘A drug called imipramine, which is used as an antidepressant in adults, may help by improving the child's sleep patterns or affecting the way the bladder muscles of the bladder work.’
    • ‘One case controlled study found no evidence that imipramine or fluoxetine increased the rate of malformations in pregnancy.’
    • ‘Desmopressin and imipramine are the primary drugs used in the treatment of nocturnal enuresis.’
    • ‘In the past, imipramine (brand name: Tofranil) was used to treat bed-wetting.’
    • ‘Desmopressin and imipramine or other tricyclics are well-known treatments for bedwetting.’
    • ‘Because he is young and has no comorbidities, imipramine at a dosage of 50 mg daily would be a reasonable first choice of medication.’
    • ‘Isolated instances of such damage have been reported with such drugs as benoxaprofen, chlorpromazine, haloperidol, imipramine, and others.’
    • ‘The herbal preparation exhibited an antidepressant effect comparable with that induced by imipramine, supporting the use of this preparation as a mood stabilizer.’
    • ‘Antidepressant medications commonly used to treat bulimia include desipramine, imipramine, and fluoxetine.’
    • ‘Most studies used amitriptyline and imipramine.’
    • ‘The authors conclude that hypericum and imipramine were therapeutically equivalent during the six-week treatment period.’
    • ‘Another class of drugs used to relax the bladder is tricyclic antidepressants, such as imipramine, nortriptyline, and desipramine.’
    • ‘When Ritalin and the antidepressant imipramine are taken together, blood levels of imipramine may be higher than expected.’
    • ‘Antidepressants included in the trials were imipramine, amitriptyline, desipramine, phenylzine, isocaboxazid, brofaramine, fluoxetine, mianserin, and bupropion.’
    • ‘Because of the tolerance profile of imipramine it was probably easy for the patients to guess whether they were receiving St John's wort or imipramine.’
    • ‘The aim of this study was to evaluate the clinical efficacy of hypericum extract and compare it with the recommended dose of imipramine, one of the most commonly used tricyclic antidepressants.’
    • ‘From this one small trial you draw the tentative conclusion that desmopressin and imipramine have similar effectiveness, and you therefore evaluate the data on adverse effects in order to determine which is the better choice.’
    • ‘An inadequate response to methylphenidate was followed first by a trial of dextroamphetamine, then pemoline and then imipramine.’
    • ‘The authors conclude that an average dosage of hypericum extract, 350 mg three times daily, appears to be as efficacious as imipramine in relieving moderate depressive symptoms.’
    • ‘Amitriptyline was the most frequently studied drug, followed by imipramine.’


1950s: from imi(ne) + pr(opyl) + amine.