Definition of frameshift mutation in English:

frameshift mutation

noun

Genetics
  • A mutation caused by the addition or deletion of a base pair or base pairs in the DNA of a gene resulting in the translation of the genetic code in an unnatural reading frame from the position of the mutation to the end of the gene.

    • ‘This frameshift mutation (deletion at positions 1151-1160) could be merely drifting to high frequency due to weak functional constraint.’
    • ‘In ORF 2 there is a deletion of 11 nucleotides that causes a frameshift mutation and a premature stop codon; an additional 1 bp insertion is located further downstream.’
    • ‘Thus, the base deletion that causes the frameshift mutation is present in the RNA population that was amplified as well as in the genomic DNA.’
    • ‘We estimate that reversion of the lac mutation is about one-tenth as likely as a null frameshift mutation in a typical gene.’
    • ‘The 25-bp insertion causes a frameshift mutation and creates stop codons in all three reading frames.’

Pronunciation:

frameshift mutation

/ˈfreɪmʃɪft mjuˌteɪʃ(ə)n/