Definition of fixative in English:

fixative

noun

  • 1A chemical substance used to preserve or stabilize biological material prior to microscopy or other examination.

    ‘an alcoholic fixative’
    mass noun ‘ten double drops of fixative’
    • ‘When individual factors in fixation were studied, some fixatives performed better than others.’
    • ‘The cultures were pooled after adding the fixative.’
    • ‘After three subsequent changes of fixative, metaphases were prepared by dropping the cell suspension onto labelled clean, moist microscope slides.’
    • ‘Osmium tetroxide was used as a secondary fixative and stain prior to a second wash in phosphate buffer.’
    • ‘Before squashing, the roots were washed in water to remove the fixative.’
    • ‘Squashes were made in the fixative on a glass slide and flame dried.’
    • ‘As much sea water as possible was removed from the samples and 4-5 volumes of cocktail fixative were added.’
    • ‘For histopathological observation, interphalangeal joint of right hind paw was sliced and placed in fixative of 10% formaline.’
    • ‘The brushes can be rinsed in saline solution or in liquid-based fixative for cell concentration procedures.’
    • ‘A technology that is being developed and refined at present is a fixative that allows blood samples to be stored and transported over 5 days without loss of accuracy in test results.’
    • ‘A liquid fixative was deliberately not used in order to prevent dislodging of pollen grains.’
    • ‘There is no single fixative that is ideal; every fixative has positive and negative attributes.’
    • ‘Squashes were made in the fixative on a coverslip.’
    • ‘The residual material that remained on the collection device was then transferred to the liquid fixative and a second slide was prepared in the laboratory.’
    • ‘Tissue samples are preserved in formalin or occasionally other fixatives before processing and embedding in paraffin.’
    • ‘This approach preserves native structure by rapidly freezing the specimen in a thin aqueous layer by plunging into cryogen, without the use of fixatives or stains.’
    • ‘Because of this, a variety of fixatives are used to preserve and stabilize certain structures and inclusions to withstand the procedures just outlined.’
    • ‘The chemical composition of each of these fixatives as detailed by the manufacturers is listed in Table 1.’
    • ‘The main purpose of chemical fixatives is to preserve the tissue, changing its fresh liquid sol state to a hardened preserved fixed state.’
    • ‘They had better success, after much trial and error, by using a one-step cocktail fixative.’
    1. 1.1 A substance used to stabilize the volatile components of perfume.
      ‘sandalwood is regarded by many perfumers as a good fixative’
      • ‘This plant is one of the natural sources of Benzyl benzoate, an aromatic liquid used as a fixative and solvent in the manufacture of flavorings and perfume.’
      • ‘Finally, while the fixatives provide the background, the base note lends the perfume its lasting impression.’
      • ‘Ambergris is used as a fixative in the manufacture of perfume.’
    2. 1.2 A liquid sprayed on to a pastel or charcoal drawing to fix colours or prevent smudging.
      ‘he sprayed his design with fixative’
      • ‘When the class had the backgrounds rendered with about four to six values, we held a class critique to evaluate if they had developed their contrast enough to go ahead and spray the artwork with workable fixative.’
      • ‘Gelatine, an animal by-product rich in collagen, was frequently used by Middle Age painters as a fixative to bind pigments to canvas or wood.’
      • ‘The art is delicately done on a textured paper and a fixative is applied before mounting.’
      • ‘But the real emphasis of this book is in developing an understanding of how the body moves and the many media and techniques for rendering the human form: chalks, charcoal, pastel, fixative, watercolors and oil paints.’
      • ‘Afterwards all the new art studenty types sprayed all their drawings creating a cloud of pungent fixative in the basement studio.’
      • ‘The top bid was $7,500 for the painting whose intensity and tactile quality are achieved with layers of charcoal, then fixative, then more layers, then sand-paper.’
      • ‘Pictographs also are fragile, since prehistoric artisans do not appear to have used any fixative, such as animal fat, in their pigments.’
      • ‘In the evening, back home, rummaging about in my big box of old art materials I came across a can of spray fixative and two bottles of spirit varnish.’
  • 2A substance used to keep things in position or stick them together.

    ‘the swift glues these thin twigs to a wall using its own saliva as a fixative’
    • ‘The team will create a new fixative mixture that combines minerals and slow-release growth factors.’
    • ‘Use a fixative, if available, for stabilization.’
    • ‘Applying the fixatives before dyeing gives both fiber components of the fabric a positive charge.’
    • ‘Especially when the greying crims could only be called hard-bitten if they'd managed to apply their denture fixative that morning.’
    • ‘The book dummies, storyboards, jacket covers, and double page spreads were proudly displayed, still smelling strongly of glue and fixatives.’
    adhesive, glue, gum, paste, bonding, binder, sealer, sealant
    View synonyms

adjective

  • (of a substance) used to fix or stabilize something.

    • ‘Mosquitoes were preserved in fixative solution and stored at - 20° until use.’
    • ‘No asbestos bodies or uncoated asbestos fibers were found in any other water or fixative samples.’
    • ‘Instead, the sample is placed in a small bottle containing fixative solution.’
    • ‘The eyes remained in the fixative solution overnight.’
    • ‘The sandals are sewn by hand, made with low-impact, fiberreactive dyes and no fixative chemicals.’
    • ‘They determined whether use of fixative fluid, organic solvent, or both might contribute to the low numbers.’
    • ‘The macerated cells were dissociated in a clean slide with a fresh fixative solution.’
    • ‘After a fixative solution is added, the sample is run on the instrument.’
    • ‘The remaining fixative solution and 5% KOH solution were examined under a microscope to determine whether pollen grains had been removed from stigmas during the treatment.’
    • ‘This fixation step was repeated twice and the resulting cells were resuspended in a small volume of fixative solution and carefully placed onto clean slides.’
    • ‘The fixative solution was partially but not completely removed, the pellet was resuspended, dropped onto pre-cleaned microscope slides and dried for 24 h at room temperature.’
    • ‘We believe that this is contamination that occurred during the process of lifting the coagulum from the dish and transferring it to the fixative solution.’
    • ‘The muscles were stored in the fixative solutions at 4 deg C for further use.’
    • ‘The best option for those with older printers is to use a fixative spray.’
    • ‘It appears that the use of tissue that had been formalin fixed before processing stabilized the uncoated asbestos fibers, since none were detected in the wash or fixative solutions.’
    • ‘The globe should be fixed in an adequate volume of fixative with at least a 10: 1 ratio of fixative volume to specimen volume recommended.’
    • ‘In the early 1970s, the use of the fixative paste was eliminated, which meant that tissue could be removed and processed immediately by frozen section.’
    • ‘A second motor initiation, which depresses a plunger in a manner similar to a syringe, combines the cell culture mixture with a fixative reagent, which squelches further biological reaction.’

Pronunciation

fixative

/ˈfɪksətɪv/