Definition of endonuclease in English:



  • An enzyme which cleaves a polynucleotide chain by separating nucleotides other than the two end ones.

    • ‘The second involves the joining of DNA ends through the pairing of short complementary sequences, as happens with complementary overhanging DNA ends produced by endonucleases.’
    • ‘Primers and endonucleases are used in the cloning of the various constructs.’
    • ‘Let us remember that they are concerned with a DNA endonuclease, so I had some experience dealing with an enzyme that cut nucleic acids.’
    • ‘These blocked forks could potentially be processed into DNA breaks by an endonuclease.’
    • ‘Total DNA was prepared from leaves of barley after 7 days of germination and restricted with appropriate endonucleases.’