Definition of disulfiram in English:



mass nounMedicine
  • A synthetic compound used in the treatment of alcoholics to make drinking alcohol produce unpleasant after-effects.

    Alternative name: tetraethylthiuram sulphide; chemical formula: (C₂H₅)₂NCSSCN(C₂H₅)₂

    Also called Antabuse (a trademark)
    • ‘Occasionally the modestly toxic disulfiram (Antabuse ®) is useful.’
    • ‘The rationale for disulfiram in treating alcoholism is that most alcoholics taking disulfiram will not drink for fear of getting sick.’
    • ‘Consuming alcohol after taking disulfiram results in symptoms such as palpitations, flushing, nausea, vomiting, and headache.’
    • ‘Outcomes of patients who take disulfiram are improved when the drug is taken under supervision.’
    • ‘I inform my alcohol-dependent patients that disulfiram, at a nickel per pill, may be viewed as inexpensive.’


1940s: blend of disulfide (see disulphide) and thiuram (from thio- + urea + amide).