One of the mysteries of the English language finally explained.
1A segment of DNA containing short repetitions of base sequences, involved in the defence mechanisms of prokaryotic organisms to viruses.
CRISPR sequences encode RNAs that can recognize specific target sequences in a genome, at which base pairs can be cut or added. They act in a complex with a specific protein that functions like a pair of molecular scissors, with which they are used as a tool in genetic engineering
- ‘The genome of P. carbinolicus contains clustered regularly interspaced short palindromic repeats (CRISPR) separated by unique spacer sequences.’
- ‘researchers first noticed some of this DNA in E.coli, and much later it was named CRISPR—clustered regularly interspaced short palindromic repeats.’
- ‘Researchers detail in 'H-NS-mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO,' new data in Escherichia coli.’
- ‘The majority of identified CRISPR loci are associated with a set of conserved protein-encoding genes termed cas (CRISPR-associated genes).’
- ‘Table 1 gives a description of CRISPR regions in Streptococcus pneumoniae and viridans group streptococci.’
- 1.1 A genetic engineering tool that uses a CRISPR sequence of DNA and its associated protein to edit the base pairs of a gene.‘using the genome editing tool known as CRISPR, researchers were able to selectively silence two genes in human papillomavirus’
- ‘This limited the CRISPR system to its minimal functional components and thus illuminated its potential as a powerful genome editing tool.’
- ‘This would be done using the genomic editing tool known as CRISPR-Cas9.’
- ‘The CRISPR Design Tool was developed by the Feng Zhang laboratory at MIT.’
- ‘The CRISPR/Cas9 design algorithm at this site allows users to input DNA sequence.’
- ‘Crispr has been developed from a mechanism used by some bacteria to defend themselves against viruses.’
Early 21st century: short for clustered regularly interspaced short palindromic repeat.
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