Definition of colony-stimulating factor in English:

colony-stimulating factor


  • A substance secreted by bone marrow which promotes the growth and differentiation of stem cells into colonies of specific blood cells.

    • ‘The maturation of white blood cells in the bone marrow and their release into the circulation are influenced by colony-stimulating factors, interleukins, tumor necrosis factor and complement components.’
    • ‘They are a large group of molecules and include the interferons, interleukins, and various colony-stimulating factors (CSFs).’
    • ‘Patients treated with granulocyte-macrophage colony-stimulating factor (GM-CSF) had significantly improved blood flow around blocked heart arteries compared with those who received a placebo.’
    • ‘Importantly, granulocyte-monocyte colony-stimulating factor has been demonstrated to improve gas exchange in a small series of patients with severe sepsis and respiratory dysfunction.’
    • ‘Growth factors are members of the cytokine family, which includes interleukins and colony-stimulating factors.’