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The region of a chromosome to which the microtubules of the spindle attach, via the kinetochore, during cell division.
- ‘In fact, we did not find any informative marker in the three chromosomal divisions around the centromere of this chromosome.’
- ‘We observed an accumulation of cDNA loci near the centromere for seven chromosomes.’
- ‘We conclude that chromosomes with damaged centromeres fail to correctly attach to the spindle, thus producing MN and monosomy.’
- ‘The pertinent variable in this form of meiotic drive is the presence of differing numbers of centromeres on paired homologous chromosomes.’
- ‘The presence of a kinetochore spot indicates the centromere region of each chromosome.’
Early 20th century (originally denoting a region within the oocyst of a malaria parasite): from Latin centrum (see centre) + Greek meros ‘part’. The current sense dates from the 1930s.
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