Definition of biomarker in English:



  • A naturally occurring molecule, gene, or characteristic by which a particular pathological or physiological process, disease, etc. can be identified.

    • ‘Cytogenetic damage, evaluated as chromosomal aberrations, has been successfully applied as a reliable biomarker for chronic health risk.’
    • ‘It is important to examine other biomarkers, such as chromosome aberrations and micronuclei, that relate to the damage still present after cellular processing.’
    • ‘In our laboratory we have adapted a similar strategy to that reported by Liu et al. to perform on-line sample dialysis and clean-up for several protein biomarkers.’
    • ‘A variance decomposition analysis was performed to reveal the extent to which platform error influenced the ability to identify biomarkers.’
    • ‘If biomarkers for the disease are present in the patient's sample, the lab-on-a-chip analysis will separate fluorescent antibodies bound to the biomarker from unbound antibodies.’
    • ‘Moreover, it has helped us identify species and biomarkers that may better contribute to establishing the quality and extent of the toxicological impact.’
    • ‘Several biomarkers for genetic susceptibility which are also associated with increased cancer risk have been identified.’
    • ‘Diet is an important variable in determining DNA damage biomarkers, specifically micronuclei.’
    • ‘Protein biomarkers offer great potential to improve the predictivity of animal studies and, in particular, provide the bridge between effects in animals and in man.’
    • ‘In addition, a better integration will facilitate the discovery of genes for novel biomarkers and targets for new therapeutic interventions.’
    • ‘Molecular diagnostics is a branch of clinical diagnostics that uses primarily DNA or RNA as a biomarker for clinical testing.’
    • ‘Proteins linked to cancer may then serve as biomarkers to detect early disease and predict responsiveness to therapy or the likelihood of recurrence.’
    • ‘Your lab is now searching for biomarkers, proteins in the blood that are linked to the presence of particular cancers.’
    • ‘The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen.’
    • ‘Under such circumstances, the identification of noninvasive or minimally invasive biomarkers of disease activity is essential.’
    • ‘Plasma concentration of homocysteine is a good biomarker for folate deficiency.’
    • ‘The gene expression biomarkers of caloric restriction can also be used to develop pharmaceuticals targeted to its genomic effects.’
    • ‘Several biomarker studies have examined the impact of vitamin E supplementation on biomarkers of DNA damage.’
    • ‘If this were the case, increased intake of beta-carotene would not be expected to protect against disease since it was a biomarker of some other process and not indicative of low dietary intake.’
    • ‘The compounds identified include biomarkers: compounds that can be related to identifiable biological chemical ‘species’.’