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[mass noun] An antidepressant drug of the tricyclic group, with a mild tranquillizing action.
- ‘For example, the anti-depressant drug amitriptyline has been shown to help prevent some chronic headaches when taken in small doses (lower than that used to treat depression) before going to bed every night.’
- ‘Tricyclic antidepressants, including amitriptyline, can cause weight gain, drowsiness, and anticholinergic symptoms.’
- ‘The most useful drugs are anticonvulsants, especially gabapentin and carbamazepine, and tricyclic antidepressants, especially amitriptyline.’
- ‘Of the tricyclic antidepressants, amitriptyline appears to be the most efficacious in the treatment of diabetic neuropathy when compared to placebo.’
- ‘Tricyclic antidepressants, such as amitriptyline and desipramine, have shown excellent pain control.’
1960s: from ami(ne) + tri- + ( he)ptyl + -ine.
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