Definition of amitriptyline in English:



mass nounMedicine
  • An antidepressant drug of the tricyclic group, with a mild tranquillizing action.

    • ‘Tricyclic antidepressants, including amitriptyline, can cause weight gain, drowsiness, and anticholinergic symptoms.’
    • ‘Of the tricyclic antidepressants, amitriptyline appears to be the most efficacious in the treatment of diabetic neuropathy when compared to placebo.’
    • ‘The most useful drugs are anticonvulsants, especially gabapentin and carbamazepine, and tricyclic antidepressants, especially amitriptyline.’
    • ‘Tricyclic antidepressants, such as amitriptyline and desipramine, have shown excellent pain control.’
    • ‘For example, the anti-depressant drug amitriptyline has been shown to help prevent some chronic headaches when taken in small doses (lower than that used to treat depression) before going to bed every night.’


1960s: from ami(ne) + tri- + ( he)ptyl + -ine.