Definition of ague cake in English:

ague cake

noun

historical
  • An enlarged spleen (or occasionally liver) in a person suffering from malaria; (also) the condition of enlargement of the spleen, especially in malaria.

Origin

Late 16th century; earliest use found in William Langham (fl. 1597), doctor and herbalist. From ague + cake.

Pronunciation

ague cake

/ˈeɪɡjuː ˌkeɪk/