One of the mysteries of the English language finally explained.
An enlarged spleen (or occasionally liver) in a person suffering from malaria; (also) the condition of enlargement of the spleen, especially in malaria.
Late 16th century; earliest use found in William Langham (fl. 1597), doctor and herbalist. From ague + cake.
ague cake/ˈeɪɡjuː ˌkeɪk/
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